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Inventi Impact: Med Chem

Articles

  • Inventi:pmc/24281/17
    Docking, Synthesis, ADME Prediction and β-Lactamase\nInhibitory Activity of Some 2-(5-H/ chloro-((piperazin-1-ylmethyl)-\n2-oxoindolin-3-ylidene)-N-substituted\nHydrazinecarbothioamides
    01-Jan-2018 Research 2018 : January - March
    Amol A Kulkarni*, Maruti V Pise, Bhushan D Varpe, Vrushali A Kulkarni

    Various 2-(5-H/chloro-((piperazin-1-yl-methyl)-2-oxoindolin-3-ylidene)-N-substittuted hydrazine carbothioamides\n4aââ?¬â??j were synthesized. The compounds were screened and evaluated for their Ã?²-Lactamase inhibitory activity with potassium\nclavulanate as a standard, amongst screened and evaluated chemical compounds. The compound 4e shown highest Ã?²-Lactamase\ninhibitory activity which was equivalent to standard Ã?²-Lactamase inhibitor, potassium clavulanate.

    How to Cite this Article
    Amol A Kulkarni, Maruti V Pise,\nBhushan D Varpe et al. Docking, Synthesis, ADME\nPrediction and β-Lactamase Inhibitory Activity of Some\n2-(5-H/ chloro-((piperazin-1-yl-methyl)-2-oxoindolin-3-\nylidene)-N-substituted Hydrazine Carbothioamides.\nInventi Impact: Med Chem, 2018(1):10-15, 2018.
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